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nf κb pathway inhibitor bay 11 7082  (MedChemExpress)


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    MedChemExpress nf κb pathway inhibitor bay 11 7082
    Nf κb Pathway Inhibitor Bay 11 7082, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 98/100, based on 552 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/nf κb pathway inhibitor bay 11 7082/product/MedChemExpress
    Average 98 stars, based on 552 article reviews
    nf κb pathway inhibitor bay 11 7082 - by Bioz Stars, 2026-02
    98/100 stars

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    nuclear factor kappa b nf κb pathway inhibitor bay 11 7 082  (MedChemExpress)
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    Butyrate inhibits PEDV replication via GPR43 <t>and</t> <t>NF-κB</t> in IPEC-J2 cells. (A) The effect of MPN, GLPG0974, and <t>BAY</t> 11–7,085 on IPEC-J2 cell. Compounds at concentrations of 0 nM, 10 nM, 100 nM, and 1 μM were added to IPEC-J2 cells and cultured for 48 h. Cell viability was evaluated using the CCK-8 assay. (B) IPEC-J2 cells were treated with 1 mM butyrate and 500 nM BAY 11–7,085 for 24 h and then infected with PEDV. PEDV RNA levels were detected using qPCR. (C) IPEC-J2 cells were treated with 1 mM butyrate and 1 μM MPN for 24 h and then infected with PEDV. PEDV RNA levels were detected using qPCR (D) IPEC-J2 cells were treated with 1 mM butyrate and 500 nM GLPG0974 for 24 h and then infected with PEDV. PEDV RNA levels were detected using qPCR. (E) IPEC-J2 cells were transfected with FFAR2 shRNA plasmids for 24 h. FFAR2 mRNA expression levels were detected using qPCR. shNC, control shRNA; shFFAR2, shRNA against FFAR2 . (F) IPEC-J2 cells were transfected with FFAR2 shRNA plasmids and pretreated with butyrate for 24 h. PEDV RNA levels were detected using qPCR. (G) IPEC-J2 cells were treated with 1 mM butyrate and 500 nM BAY 11–7,085 for 24 h and then infected with PEDV. Effects <t>of</t> <t>BAY</t> <t>11–7,082</t> on virus-induced phosphorylation of IκBα. Protein levels detected by western blotting. (H) IPEC-J2 cells were treated with 1 mM butyrate for 24 h. FFAR2 mRNA expression levels were detected using qPCR.
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    Butyrate inhibits PEDV replication via GPR43 and NF-κB in IPEC-J2 cells. (A) The effect of MPN, GLPG0974, and BAY 11–7,085 on IPEC-J2 cell. Compounds at concentrations of 0 nM, 10 nM, 100 nM, and 1 μM were added to IPEC-J2 cells and cultured for 48 h. Cell viability was evaluated using the CCK-8 assay. (B) IPEC-J2 cells were treated with 1 mM butyrate and 500 nM BAY 11–7,085 for 24 h and then infected with PEDV. PEDV RNA levels were detected using qPCR. (C) IPEC-J2 cells were treated with 1 mM butyrate and 1 μM MPN for 24 h and then infected with PEDV. PEDV RNA levels were detected using qPCR (D) IPEC-J2 cells were treated with 1 mM butyrate and 500 nM GLPG0974 for 24 h and then infected with PEDV. PEDV RNA levels were detected using qPCR. (E) IPEC-J2 cells were transfected with FFAR2 shRNA plasmids for 24 h. FFAR2 mRNA expression levels were detected using qPCR. shNC, control shRNA; shFFAR2, shRNA against FFAR2 . (F) IPEC-J2 cells were transfected with FFAR2 shRNA plasmids and pretreated with butyrate for 24 h. PEDV RNA levels were detected using qPCR. (G) IPEC-J2 cells were treated with 1 mM butyrate and 500 nM BAY 11–7,085 for 24 h and then infected with PEDV. Effects of BAY 11–7,082 on virus-induced phosphorylation of IκBα. Protein levels detected by western blotting. (H) IPEC-J2 cells were treated with 1 mM butyrate for 24 h. FFAR2 mRNA expression levels were detected using qPCR.

    Journal: Frontiers in Microbiology

    Article Title: Butyrate limits the replication of porcine epidemic diarrhea virus in intestine epithelial cells by enhancing GPR43-mediated IFN-III production

    doi: 10.3389/fmicb.2023.1091807

    Figure Lengend Snippet: Butyrate inhibits PEDV replication via GPR43 and NF-κB in IPEC-J2 cells. (A) The effect of MPN, GLPG0974, and BAY 11–7,085 on IPEC-J2 cell. Compounds at concentrations of 0 nM, 10 nM, 100 nM, and 1 μM were added to IPEC-J2 cells and cultured for 48 h. Cell viability was evaluated using the CCK-8 assay. (B) IPEC-J2 cells were treated with 1 mM butyrate and 500 nM BAY 11–7,085 for 24 h and then infected with PEDV. PEDV RNA levels were detected using qPCR. (C) IPEC-J2 cells were treated with 1 mM butyrate and 1 μM MPN for 24 h and then infected with PEDV. PEDV RNA levels were detected using qPCR (D) IPEC-J2 cells were treated with 1 mM butyrate and 500 nM GLPG0974 for 24 h and then infected with PEDV. PEDV RNA levels were detected using qPCR. (E) IPEC-J2 cells were transfected with FFAR2 shRNA plasmids for 24 h. FFAR2 mRNA expression levels were detected using qPCR. shNC, control shRNA; shFFAR2, shRNA against FFAR2 . (F) IPEC-J2 cells were transfected with FFAR2 shRNA plasmids and pretreated with butyrate for 24 h. PEDV RNA levels were detected using qPCR. (G) IPEC-J2 cells were treated with 1 mM butyrate and 500 nM BAY 11–7,085 for 24 h and then infected with PEDV. Effects of BAY 11–7,082 on virus-induced phosphorylation of IκBα. Protein levels detected by western blotting. (H) IPEC-J2 cells were treated with 1 mM butyrate for 24 h. FFAR2 mRNA expression levels were detected using qPCR.

    Article Snippet: The GPR109a inhibitor Mepenzolate bromide (MPN) (HY-17585) and the nuclear factor kappa B (NF-κB) pathway inhibitor BAY 11–7,082 (HY-13453) were obtained from MedChemExpress (Monmouth Junction, NJ, USA).

    Techniques: Cell Culture, CCK-8 Assay, Infection, Transfection, shRNA, Expressing, Control, Virus, Phospho-proteomics, Western Blot

    A model for regulation of anti-PEDV innate immunity by butyrate. Butyrate through activation of GPR43 and NF-κB, leading interferon responses and induction of downstream antiviral genes inhibition of PEDV replication.

    Journal: Frontiers in Microbiology

    Article Title: Butyrate limits the replication of porcine epidemic diarrhea virus in intestine epithelial cells by enhancing GPR43-mediated IFN-III production

    doi: 10.3389/fmicb.2023.1091807

    Figure Lengend Snippet: A model for regulation of anti-PEDV innate immunity by butyrate. Butyrate through activation of GPR43 and NF-κB, leading interferon responses and induction of downstream antiviral genes inhibition of PEDV replication.

    Article Snippet: The GPR109a inhibitor Mepenzolate bromide (MPN) (HY-17585) and the nuclear factor kappa B (NF-κB) pathway inhibitor BAY 11–7,082 (HY-13453) were obtained from MedChemExpress (Monmouth Junction, NJ, USA).

    Techniques: Activation Assay, Inhibition